General Clinical Chemistry Analyzers and Accessories
Abcam Elvitegravir, quinolone HIV integrase inhibitor, 10MG
MW 447.9 Da, Purity >99%. Elvitegravir is an inhibitor of HIV integrase. It inhibits HIV integrase from HIV 1 IIIB (IC₅₀ = 0.7 nM), HIV 2 EHO (IC₅₀ = 2.8 nM) and HIV-2 ROD (IC₅₀ = 1.1 nM) in cell free assays. Elvitegravir blocks integration of HIV cDNA via inhibition of DNA strand transfer. Active against a range of HIV sub-types and against mulit-drug resistant clinical isolates. Potent (IC₅₀ range = 0.21 - 1.15 nM) HIV antiviral activity in various cell-based assays.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GLPG-1690, 5MG
MW 588.7 Da, Purity >=98%. Selective autotaxin inhibitor with potential application in idiopathic pulmonary disease (IPF).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ponesimod, sphingosine-1-phophate receptor agonist, 1MG
MW 461 Da. Ponesimod is a potent agonist of sphingosine-1-phophate receptor. (S1P₁/EDG-1; IC₅₀s = 6, >10,000, 2,068, 1,956, and 142 nM for S1P₁-S1P₅, respectively, in a radioligand binding assay). Selectively activates S1P₁ in a GTPγS assay (EC₅₀s = 5.7, >10,000, 105, 1,108, and 59.1 nM, for S1P₁-S1P₅, respectively).
The product is subject to the following: Abcam Restricted Use Statement
Abcam RITA, p53 activator, 25MG
MW 292.4 Da, Purity >98%. p53 activator. Tricyclic thiophene derivative that binds to p53 and induces its accumulation in tumor cells. Prevents p53-HDM2 (MDM2) interaction in vitro and in vivo and affects p53 interaction with several negative regulators. Induces expression of p53 target genes and apoptosis in various tumor cell lines expressing wild-type p53.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Amisulbrom
Chemical. CAS 348635-87-0. Formula C13H13BrFN5O4S2. MW 466.31. Synthetic. Oomycete-specific sulphonamide fungicide which acts by inhibiting mitochondrial complex III activity Complex III cytochrome bc1 ubiquinone reductase through binding to the Qi centre and impairing respiration and energy production. Categorized as quinine insider inhibitor QII. Shown to have anti-fouling activity. Compound can be used as analytical reference material.
AdipoGen Rhodamine 6G hexanediamine ami
Chemical. CAS 1140505-40-3. Formula C32H40N4O2 . C4H2F6O4. MW 740.73. Synthetic. N-6-Aminohexylrhodamine 6G-amide bistrifluoroacetate is a rhodamine 6G-amide derivative useful as a bioreagent in fluorescence assays.
(CCCC)C#CC | 1g | 525924058](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502696556.jpg-250.jpg)
eMolecules 64099-82-7 | Tributyl(1-propynyl)tin | Synthonix - Stock | MFCD01863650 | 329.115 | C15H30Sn | 95.000 | CCCC[Sn](CCCC)(CCCC)C#CC | 1g | 525924058
Tributyl(1-propynyl)tin | Synthonix - Stock | 64099-82-7 | MFCD01863650 | 329.115 | C15H30Sn | 95.000 | CCCC[Sn](CCCC)(CCCC)C#CC | 1g | 525924058
AdipoGen Thifluzamide
Chemical. CAS 130000-40-7. Formula C13H6Br2F6N2O2S. MW 528.1. Synthetic. Thiazole fungicide used in agrochemistry. Succinate dehydrogenase inhibitor SDHI which interferes with succinate ubiquinone reductase in the mitochondrial electron transport chain of fungi.Compound can be used as analytical reference material.
Abcam SGI1776, 5MG
MW 405.4 Da, Purity >99%. Novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3. Preliminary results from studies treating prostate cancer cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ro 08-2750, 10MG
MW 270.24 Da, Purity =98%. An antagonist of nerve growth factor (NGF) with binding ratio of 1:1, IC₅₀ = 1 μM. Selectively inhibits binding to p75NTR over TRKA147 at low concentrations. However, it can impair NGF binding to TrkA at higher concentrations (more than 5 mM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ticagrelor, P2Y12 receptor antagonist, 25MG
MW 522.6 Da, Purity >98%. Reversible antagonist of the platelet purinergic P2Y12 receptor, the main receptor responsible for ADP-induced platelet aggregation. Changes the conformation of the P2Y12 receptor, resulting in reversible, concentration dependent inhibition of the receptor.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Amisulbrom
Chemical. CAS 348635-87-0. Formula C13H13BrFN5O4S2. MW 466.31. Synthetic. Oomycete-specific sulphonamide fungicide which acts by inhibiting mitochondrial complex III activity Complex III cytochrome bc1 ubiquinone reductase through binding to the Qi centre and impairing respiration and energy production. Categorized as quinine insider inhibitor QII. Shown to have anti-fouling activity. Compound can be used as analytical reference material.
Abcam UC2288, p21 inhibitor, 5MG
MW 481.8 Da, Purity >98%. Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI₅₀ = ~ 10 μM against NCI60 cell lines).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Dovitinib, class III-V receptor tyrosine kinase inhibitor, 25MG
MW 392.4 Da, Purity >99%. Potent, selective inhibitor of class III-V receptor tyrosine kinases (RTKs). Inhibits FLT3 (IC₅₀ = 1 nM), c-KIT (IC₅₀ = 2 nM), FGFR (IC₅₀ = 8 nM), VEGFR1/2/3 (IC₅₀ values are 10 nM, 13 nM and 8 nM respectively), PDGFRβ (IC₅₀ = 27 nM), and CSF-1R (IC₅₀ = 36 nM). Selectively blocks growth of B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Anidulafungin, 25MG
MW 1140.2 g/mol, Purity >=95%. Inhibits fungal (1→3)-β-D-glucan synthase. Potent in vitro activity against Aspergillus and Candida species (MIC₅₀ of 0.03 to 4 μg/ml), including those resistant to fluconazole or amphotericin B. Effective in treating esophageal candidiasis in clinical trials.
The product is subject to the following: Abcam Restricted Use Statement